超全的新冠病毒突變蛋白試劑庫-國內聚焦-資訊-生物在線

超全的新冠病毒突變蛋白試劑庫

作者：北京義翹神州科技有限公司 2021-06-02T14:33 (訪問量:30202)

重組Spike突變體N501Y

最近幾個月，全球范圍內分離出了多種新的新冠突變毒株。其中，U.K. variant B.1.1.7，the Brazil variant P.1，the South Africa variant B.1.351以及最新分離出的Indian variant B.1.617 具有很高的傳染率，也因此備受關注。

在目前已經檢測分離到的新冠突變株中，發生在Spike蛋白受體結合域的多個突變是主要的突變類型，也是最令人擔心的突變。Spike蛋白受體結合域是新冠病毒結合宿主受體的主要結構，該結構的突變則有可能導致增強與受體的親和力、減弱中和抗體效應或者造成病毒的免疫逃逸。

新冠突變株中同時存在N蛋白突變。N蛋白具有高度保守型，常被用作新冠抗原快速檢測的標志物。目前已經上市的新冠抗原檢測試劑是否可以檢測到突變后的N蛋白以及檢測靈敏度和特異性是否會受到突變的影響需要進一步的研究。

義翹神州開發了近150種新冠突變體蛋白，可用于抗體、疫苗等效力研究。

新冠突變體蛋白試劑庫

B.1.617 (India*)

毒株 貨號 抗原 突變位點 標簽
B.1.617 40588-V07E16 N D377Y His
B.1.617 40588-V07E20 (under development) N R203M, D377Y His
B.1.617 40589-V08B12 (under development) S1+S2 ECD D614G, E154K, E484Q, E1072K, K1073R, L452R, P681R His
B.1.617 40589-V08B13 (under development) S1+S2 ECD D614G, E154K, E484Q, G142D, H1101D, L452R, P681R, Q1071H His
B.1.617 40591-V08H19 S1 D614G, E154K, E484Q, L452R, P681R His
B.1.617 40592-V08H28 RBD L452R His
B.1.617 40592-V08H81 RBD E484Q His
B.1.617/B.1.617.1/b.1.617.3 40592-V08H88 RBD L452R，E484Q His
B.1.617.2 40592-V08H90 (under development) RBD L452R,T478K His
B.1.617/B.1.617.1/b.1.617.3 40592-V02H2 (under development) RBD L452R，E484Q Fc
B.1.617.2 40592-V02H3 (under development) RBD L452R,T478K Fc
B.1.617.1 40589-V08B15 (under development) S1+S2 ECD T95I,G142D, E154K, L452R,E484Q, D614G, P681R,Q1071H His
B.1.617.2 40589-V08B16 (under development) S1+S2 ECD T19R, G142D, del157/158, L452R,T478K, D614G, P681R, D950N His
B.1.617.3 40589-V08B17 (under development) S1+S2 ECD T19R, L452R, E484Q,D614G, P681R, D950N，G142D His
B.1.617.1 40591-V08H22 (under development) S1 T95I,G142D, E154K, L452R,E484Q, D614G, P681R His
B.1.617.2 40591-V08H23 (under development) S1 T19R, G142D, E156G，del157/158, L452R,T478K, D614G, P681R His
B.1.617.3 40591-V08H24 (under development) S1 T19R, L452R, E484Q,D614G, P681R，G142D His

Epsilon | B.1.427/B.1.429 (U.S.A*)

毒株 貨號 抗原 突變位點 標簽
B.1.429/B.1.427 40591-V08H17 S1 W152C, L452R, D614G His
B.1.429/B.1.427 40588-V07E9 N T205I His

Alpha | B.1.1.7 (U.K.*)

毒株 貨號 抗原 突變位點 標簽
B.1.1.7 40588-V07E1 N R203K, G204R His
B.1.1.7 40588-V07E17 N E378Q His
B.1.1.7 40588-V07E4 N I292T His
B.1.1.7 40588-V07E7 N D3L, R203K, G204R, S235F His
B.1.1.7 40588-V07E8 N D3L, S235F His
B.1.1.7 40589-V08B6 S1+S2 ECD H69del, V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H His
B.1.1.7 40591-V08H12 S1 H69del, V70del, Y144del, N501Y, A570D, D614G, P681H His
B.1.1.7 40591-V08H12-B S1-Biotinylated H69del, V70del, Y144del, N501Y, A570D, D614G, P681H His
B.1.1.7 40591-V08H7 S1 HV69-70 deletion, N501Y, D614G His
B.1.1.7 40592-V02H1 RBD N501Y Fc
B.1.1.7 40592-V08H18 RBD S494P His
B.1.1.7 40592-V08H82 RBD N501Y His
B.1.1.7 40592-V08H82-B RBD-Biotinylated N501Y His
B.1.1.7 40592-V31H1 (under development) RBD N501Y rFc
B.1.1.7, B.1.237 40588-V07E3 N S194L His
B.1.1.7, B.1.351, A.2.2 40588-V07E2 N P13L His

Beta | B.1.351 (South Africa*)

毒株 貨號 抗原 突變位點 標簽
B.1.351 40588-V07E9 N T205I His
B.1.351 40589-V08B11 S1+S2 ECD D80A, L242del, A243del, L244del, R246I, E484K, K417N, N501Y, D614G, A701V His
B.1.351 40589-V08B7 S1+S2 ECD L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V His
B.1.351 40589-V08B7-B S1+S2-Biotinylated L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V His
B.1.351 40589-V08B9 S1+S2 ECD D80A, K417N, E484K, N501Y, D614G, A701V His
B.1.351 40591-V08H10 S1 K417N, E484K, N501Y, D614G His
B.1.351 40591-V08H13 S1 NTD L18F, D80A, D215G, LAL242-244 deletion, R246I His
B.1.351 40591-V08H15 S1 L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G His
B.1.351 40592-V08H59 RBD K417N His
B.1.351 40592-V08H59-B RBD-Biotinylated K417N His
B.1.351 40592-V08H84 RBD E484K His
B.1.351 40592-V08H84-B RBD-Biotinylated E484K His
B.1.351 40592-V08H85 RBD K417N, E484K, N501Y His
B.1.351 40592-V08H85-B RBD-Biotinylated K417N, E484K, N501Y His
B.1.351 40592-V02H4 (under development) RBD K417N, E484K, N501Y Fc
B.1.351 40592-V31H2 (under development) RBD E484K rFc
B.1.351 40592-V31H4 (under development) RBD K417N, E484K, N501Y rFc
B.1.351 40592-V31H6 (under development) RBD K417N rFc
B.1.351,B.1.427,B.1.429 40588-V07E24 (under development) N T205I,A220V,P13L His

Gamma | P.1 (Brazil*)

毒株 貨號 抗原 突變位點 標簽
P.1 40588-V07E11 N P80R His
P.1 40589-V08B10 (under development) S1+S2 ECD L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F His
P.1 40589-V08B8 S1+S2 ECD L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I His
P.1 40591-V08H14 S1 L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y His
P.1 40591-V08H5 S1 T20N, D614G His
P.1 40592-V08H86 RBD K417T, E484K, N501Y His
P.1 40592-V02H5 (under development) RBD K417T, E484K, N501Y Fc
P.1 40592-V31H5 (under development) RBD K417T, E484K, N501Y rFc
P.1 40592-V31H7 (under development) RBD K417T rFc

Mink Variant (Denmark*)

貨號 抗原 突變位點 標簽
40591-V08H8 S1 ΔH69/ΔV70, Y453F, D614G His
40592-V08H80 RBD Y453F His
40592-V31H3 (under development) RBD Y453F rFc

High Frequency Mutation of Nucleocapsid

毒株 貨號 抗原 突變位點 標簽
High Frequency N 40588-V07E1 N R203K, G204R His
High Frequency N 40588-V07E11 N P80R His
High Frequency N 40588-V07E2 N P13L His
High Frequency N 40588-V07E3 N S194L His
High Frequency N 40588-V07E4 N I292T His
High Frequency N 40588-V07E9 N T205I His

More Variants

,
貨號 抗原 突變位點 標簽
40589-V08B14 S1+S2 ECD Y145del, H146del, E484K, D614G His
40589-V08B4 S1+S2 ECD D614G His
40589-V08B5 S1+S2 ECD HV69-70 deletion, D614G, D796H His
40590-V02H1 S2 E780Q Fc
40591-V02H3 S1 D614G Fc
40591-V08H11 S1 N234Q His
40591-V08H16 S1 Q677H His
40591-V08H21 (under development) S1 H49Y, Y145del, H146del, E484K, D614G His
40591-V08H3 S1 D614G His
40591-V08H4 S1 A222V, D614G His
40591-V08H6 S1 L18F, D614G His
40591-V08H9 S1 HV69-70 deletion, N439K, D614G His
40592-V05H1 RBD V367F mFc
40592-V08H1 RBD V367F His
40592-V08H10 RBD R408I His
40592-V08H11 RBD V341I His
40592-V08H12 RBD Y508H His
40592-V08H14 RBD N439K His
40592-V08H15 RBD V503F His
40592-V08H16 RBD A522V His
40592-V08H19 RBD A372S His
40592-V08H2 RBD N354D His
40592-V08H20 RBD A520S His
40592-V08H21 RBD A522S His
40592-V08H22 RBD D405V, Q414A His
40592-V08H23 RBD Q414E His
40592-V08H24 RBD P384L His
40592-V08H25 RBD A348S His
40592-V08H26 RBD F338L His
40592-V08H27 RBD F377L His
40592-V08H29 RBD P521S His
40592-V08H30 RBD T478I His
40592-V08H31 RBD V483I His
40592-V08H32 RBD S359N His
40592-V08H33 RBD K378R His
40592-V08H34 RBD Q409E His
40592-V08H35 RBD I472V His
40592-V08H36 RBD A372T His
40592-V08H37 RBD A344S His
40592-V08H39 RBD A520V
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