
重組抗原是感染性疾病研究中的關鍵試劑,廣泛應用于治療性抗體和疫苗開發。義翹神州自主開發了世界上最大的重組病毒抗原庫ProVirTM,其特點是擁有冠狀病毒目錄、全面的流感抗原庫以及其他許多難以找到的病毒蛋白,如寨卡病毒、呼吸道合胞病毒、埃博拉病毒和巨細胞病毒。ProVirTM病毒抗原庫包括來自90種病毒類型/亞型和350種毒株的1000多種抗原,已在全球范圍內廣泛用于傳染病研究、治療性抗體評估、免疫診斷分析和疫苗開發。
重組新冠病毒突變體
在印度首次發現的B.1.1.7突變體、P1突變體、B.1.351突變體和最近的B.1.617突變體因其流行率高而特別令人關切。義翹神州開發了一系列重組RBD/S蛋白和核衣殼蛋白突變體,可用于評估抗體和疫苗的效力。
Kappa | B.1.617.1;Delta | B.1.617.2;B.1.617.3
| 毒株 | 貨號 | 抗原 | 突變位點 | 標簽 |
| B.1.617 | 40588-V07E16 | N | D377Y | His |
| B.1.617 | 40588-V07E20 | N | R203M, D377Y | His |
| B.1.617.2 | 40588-V07E29 | N | D63G, R203M, D377Y | His |
| B.1.617.3 | 40588-V07E30 | N | P67S, R203M, D377Y | His |
| B.1.617 | 40591-V08H19 | S1 | D614G, E154K, E484Q, L452R, P681R | His |
| B.1.617 | 40589-V08B12 | S1+S2 ECD | D614G, E154K, E484Q, E1072K, K1073R, L452R, P681R | His |
| B.1.617 | 40592-V08H28 | RBD | L452R | His |
| B.1.617 | 40592-V08H81 | RBD | E484Q | His |
| B.1.617/B.1.617.1/b.1.617.3 | 40592-V08H88 | RBD | L452R,E484Q | His |
| B.1.617/B.1.617.1/b.1.617.3 | 40592-V02H2 | RBD | L452R,E484Q | Fc |
| B.1.617.2 | 40592-V08H90 | RBD | L452R, T478K | His |
| B.1.617.2 | 40592-V08H91 | RBD | T478K | His |
ProVirTM病毒庫包含250多種流感病毒株的630+ HA、NA和ME重組抗原,包括疫苗株和大流行株。義翹神州提供近年來(2015-2022年)世衛組織推薦的所有疫苗株的重組抗原。
2021-2022流感疫苗株相關重組蛋白產品
| A/Victoria/2570/2019 (H1N1) Recommended for Egg-based (quadrivalent,trivalent) Vaccine HA: 40787-V08H, 40787-V08H1 NA: 40785-V08B NP: 40774-V08B |
A/Wisconsin/588/2019 (H1N1) Recommended for Cell- or recombinant-based (quadrivalent, trivalent) Vaccine HA: 40787-V08H, 40787-V08H1 NA: 40785-V08B NP: 40774-V08B |
| B/Washington/02/2019 Recommended for Egg-based, Cell- or recombinant-based (quadrivalent, trivalent) Vaccine HA: 40722-V08H NA: 40790-V08B NP: 40755-V08B |
B/Phuket/3073/2013 Recommended for Egg-based, Cell- or recombinant-based (quadrivalent) Vaccine HA: 40498-V08B NA: 40502-V07B NP: 40500-V08B |
| A/Cambodia/E0826360/2020 (H3N2) Recommended for Egg-based, Cell- or recombinant-based (quadrivalent, trivalent) Vaccine HA: 40789-V08H, 40789-V08H1 NA: 40784-V08B NP: 40778-V08B (Under Development) |
更多傳染性病毒的重組抗原
ProVirTM病毒庫提供多種傳染病相關病毒的重組抗原,從埃博拉病毒(Ebola)、寨卡病毒(Zika)到普通病毒,如呼吸道合胞病毒(RSV)、人乳頭狀瘤病毒(HPV)和艾滋病毒(HIV)。它還有一些罕見的病毒類型,如裂谷熱和印第安納水泡性口炎病毒。
呼吸道疾病病毒
| CMV | EV-D68 | HAdV-B | HAdV-E |
| HPIV-3 | HPIV-4 | HMPV-A | HMPV-B |
| RSV | EBV | HCoV-229E | HCoV-HKU1 |
| HCoV-NL63 | HCoV-OC43 | MERS-CoV | SARS-CoV |
手足口病病毒
| EV-71 | CV |
血源性疾病病毒
| HIV | HBV | HCV |
熱帶和媒介傳播疾病
| DENV | CHIKV | WNV | ZIKV | RVFV |
更多疾病病毒
| EBOV | HTNV | HEV | VSIV |
| PCV2 | SIV | CyCMV | DcCoV |
