?Recombinant human Noggin protein
重組人指(趾)關節粘連NOG蛋白
| 英文名稱 | Recombinant human Noggin protein |
| 中文名稱 | 重組人指(趾)關節粘連NOG蛋白 |
| 別????名 | NOG; SYM 1; SYM1; Symphalangism 1 (proximal); Synostoses (multiple) syndrome 1; SYNS 1; SYNS1; NOGG_HUMAN?? |
| 理論分子量 | 23kDa |
| 性????狀 | Lyophilized or Liquid |
| 濃????度 | ＞0.5 mg/ml |
| 物????種 | Human |
| 序????列 | 28-232/232 |
| 純????度 | > 90% as determined by SDS PAGE |
| 純化方法 | AC |
| 內毒素 | Not analyzed |
| 表達系統 | HEK293 cell |
| 活性 | Not tested |
| 標簽 | Tag Free |
| 緩?沖?液 | PBS (pH=7.4) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產品介紹 | Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion. ? |
| 產品圖片 |
 The purity of the protein is greater than 80% as determined by reducing SDS-PAGE.
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本產品僅供科研使用.請勿用于醫藥,不能用于臨床治療診斷使用！