The Key Inflammasome Activators and Inhibitors - Including New Gasdermin Inhibitor
| Product Name | PID | Product Description |
| Monosodium urate (crystals) Monosodium urate (ready-to-use) |
AG-CR1-3950 AG-CR1-3951 |
Potent NLRP3 inflammasome activator. |
| Nigericin . Na | AG-CN2-0020 | Potent NLRP3 inflammasome activator. |
| N-Acetyl-D-glucosamine | AG-CN2-0489 | Acts as activator of NLRP3 inflammasome by dissociating the enzyme hexokinase from the mitochondria. |
| Necrosulfonamide NEW | AG-CR1-3705 |
Binds directly to Gasdermin D and inhibits the oligomerization of the N-terminus and therefore the pore formation and pyroptosis.
|
| U-73122 NEW | AG-CR1-3698 |
Gasdermin D N-terminal fragment (GSDMD-N)-induced pyroptosis inhibitor. Protects against GSDMD-N cytotoxicity in macrophages or against lethal infection in mice.
|
| Dapansutrile BULK AVAILABLE | AG-CR1-3535 | Potent, selective and orally active NLRP3 inflammasome inhibitor. Directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 inflammasome assembly and activation. |
| MCC950 . Na (water soluble) BULK AVAILABLE | AG-CR1-3615 | Potent and selective NLRP3 inflammasome inhibitor. |
| Isoliquiritigenin | AG-CN2-0459 |
Inhibits NLRP3-activated Asc oligomerization. Blocks priming and activation steps.
|
| BAY 11-7082 | AG-CR1-0013 | Reduces ATPase activity of the NLRP3 inflammasome. |
| (R)-3-Hydroxybutyric acid (S)-3-Hydroxybutyric acid DL-3-Hydroxybutyric acid sodium salt |
AG-CR1-3616 AG-CR1-3617 CDX-H0080 |
Prevent K+-efflux and consequently reduce Asc oligomerization and speck formation.
|
| K777 [K11777] | AG-CR1-0158 | Broad-range cathepsin inhibitor useful for inflammasome inhibition. |
| m-3M3FBS NEW | AG-CR1-3548 | Triggers mitochondrial damage and NLRP10 inflammasome activation. |
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