瘦素(Leptin)是由ob基因編碼、在脂肪組織中生成的一種脂肪代謝調控產物，在代謝和調控體重等方面發揮重要作用。它通過下丘腦中的瘦素受體發出信號，降低食欲，增加能量消耗。在外周組織中，瘦素能拮抗胰島素信號傳導，增加脂肪酸氧化，減少胰島β細胞的胰島素分泌，并促進生育。它在脂肪細胞中的表達可以被其他脂肪因子如IL-6（刺激）和TNF-α（抑制）以旁分泌方式調節。瘦素缺乏的小鼠表現出嚴重的胰島素抵抗、肥胖和生育能力下降，所有這些都可以通過外源性瘦素給藥而逆轉。
● 無邊緣效應：所有孵育步驟在常溫下進行消除了37°C下蒸發的風險
● 檢測范圍廣：易于定量檢測高水平和低水平瘦素
● 方便：所有試劑保存在4°C
● 快速：僅需3小時就可獲得39個樣本的重復結果
● 預包被板和即用型試劑為您節省實驗時間
產品信息
|
產品貨號 |
ADI-900-015A |
|
產品名稱 |
Leptin (rat), ELISA kit（大鼠瘦素ELISA試劑盒） |
|
規格 |
96 wells |
|
靈敏度 |
67.2 pg/ml |
|
檢測范圍 |
100- 6,400 pg/ml |
|
檢測時間 |
3 hours |
|
樣本種屬 |
Rat |
|
樣本類型 |
culture supernatants, plasma, and serum |
|
保存溫度 |
+4°C |
|
試劑盒組分 |
Microtiter plate, Standard, Antibody, Conjugate, Assay buffer 28, TMB Substrate, Stop solution 2, Wash buffer concentrate |
部分產品引用文獻
1. Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT::Cre+ rats: C.P. Mantanona, et al.; Brain Struct. Funct. 224, 3095 (2019)
2. Long-term feeding of red algae (Gelidium amansii) ameliorates glucose and lipid metabolism in a high fructose diet-impaired glucose tolerance rat model: H.C. Liu, et al.; J. Food Drug Anal. 25, 543 (2017), Application(s): Determination of leptin, rat plasma
3. Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus: M.M. Rahman, et al.; Biomed. Pharmacother. 92, 606 (2017)
4. Effect of Intermittent Hypoxia on Arcuate Nucleus in the Leptin-Deficient Rat: J. Ciriello, et al.; Neurosci. Lett. 626, 112 (2016), Application(s): Measured leptin levels in rat aqueous plasma phase
5. Neonatal treatment with scopolamine butylbromide prevents metabolic dysfunction in male rats: A. Malta, et al.; Sci. Rep. 6, 30745 (2016), Application(s): Leptin level quantification
6. Impact of prenatal exposure to obesogenic environment on later-life brown and white adipocytes and liver outcomes: L. Bezpalko, et al.; Proc. Shevchenko Sci. Soc. Medicine 41, 33 (2015), Application(s): ELISA using rat serum
7. Lactobionic acid reduces body weight gain in diet-induced obese rats by targeted inhibition of galectin-1: R. Mukherjee, et al.; Biochem. Biophys. Res. Commun. 463, 1311 (2015), Application(s): ELISA using rat plasma
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