產(chǎn)品介紹
BioXcell InVivoPlus anti-mouse Ly6G 1A8單克隆抗體與小鼠Ly6G反應(yīng)。Ly6G分子量為21-25kDa，是GPI錨定的細(xì)胞表面蛋白Ly-6超家族的成員，在細(xì)胞信號(hào)傳導(dǎo)和細(xì)胞粘附中發(fā)揮作用。Ly6G在發(fā)育過程中由骨髓譜系中的細(xì)胞（包括單核細(xì)胞、巨噬細(xì)胞、粒細(xì)胞和嗜中性粒細(xì)胞）差異表達(dá)。單核細(xì)胞通常在發(fā)育過程中瞬時(shí)表達(dá)Ly6G，而成熟的粒細(xì)胞和外周嗜中性粒細(xì)胞保持表達(dá)，使Ly6G成為這些群體的良好細(xì)胞表面標(biāo)志物。與BioXcell RB6-8C5抗體不同，1A8抗體與小鼠Ly6G特異性反應(yīng)，而與Ly6C沒有交叉反應(yīng)性的報(bào)道。
產(chǎn)品詳情
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產(chǎn)品名稱 |
InVivoPlus anti-mouse Ly6G |
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產(chǎn)品貨號(hào) |
BP0075-1 |
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產(chǎn)品規(guī)格 |
5/25/50/100mg |
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反應(yīng)種屬 |
Mouse |
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克隆號(hào) |
1A8 |
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同種型 |
Rat IgG2a, κ |
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免疫原 |
EL4J cells transfected with Ly6G |
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實(shí)驗(yàn)應(yīng)用 |
in vivo neutrophil depletion in vivo MDSC depletion Immunofluorescence Immunohistochemistry (paraffin) Immunohistochemistry (frozen) Flow cytometry |
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產(chǎn)品形式 |
PBS, pH 7.0,Contains no stabilizers or preservatives |
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純度 |
>95%, Determined by SDS-PAGE |
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聚合 |
<5%, Determined by SEC |
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無菌處理 |
0.2 μm filtration |
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純化方式 |
Protein G |
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RRID |
AB_1107721 |
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分子量 |
150 kDa |
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小鼠病原檢測(cè) |
Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
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保存條件 |
抗體原液保存在4°C，不能冷凍保存。 |
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推薦同型對(duì)照 |
InVivoPlus rat IgG2a isotype control, anti-trinitrophenol（貨號(hào)BP0089） |
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推薦抗體稀釋液 |
InVivoPure pH 7.0 Dilution Buffer（貨號(hào)IP0070） |
為什么選擇InVivoPlus抗體？
InVivoPlus級(jí)別的產(chǎn)品內(nèi)毒素含量更低，經(jīng)過多種實(shí)驗(yàn)驗(yàn)證，更適合用于體內(nèi)實(shí)驗(yàn)研究
該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻(xiàn)引用：
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應(yīng)用 |
文章 |
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體內(nèi)中性粒細(xì)胞耗竭 (in vivo neutrophil depletion) |
1. Davis, R. W. t., et al. (2018). 'Luminol Chemiluminescence Reports Photodynamic Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy' Photochem Photobiol . 2. Moynihan, K. D., et al. (2016). 'Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses' Nat Med. doi : 10.1038/nm.4200. 3. Conde, P., et al. (2015). 'DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance' Immunity 42(6): 1143-1158. 4. Griseri, T., et al. (2015). 'Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis' Immunity 43(1): 187-199. 5. Yamada, D. H., et al. (2015). 'Suppression of Fcgamma-receptor-mediated antibody effector function during persistent viral infection' Immunity 42(2): 379-390. 6. Ellis, G. T., et al. (2015). 'TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection' EMBO Rep 16(9): 1203-1218. 7. Deshmukh, H. S., et al. (2014). 'The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice' Nat Med 20(5): 524-530. |
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體內(nèi)中性粒細(xì)胞耗竭、流式細(xì)胞術(shù)、免疫組化石蠟切片(in vivo neutrophil depletion, Flow Cytometry, Immunohistochemistry (paraffin)) |
Coffelt, S. B., et al. (2015). 'IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis' Nature 522(7556): 345-348. |
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體內(nèi)中性粒細(xì)胞耗竭、流式細(xì)胞術(shù)、免疫組化石蠟切片、免疫組化冰凍切片(in vivo neutrophil depletion, Flow Cytometry, Immunohistochemistry (paraffin), Immunohistochemistry (frozen)) |
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