靶向細胞因子或其受體的中和抗體是研究免疫調節和開發治療策略的有力工具。InvivoGen提供多種高品質重組單克隆抗體(monoclonal antibody, mAb)，這些抗體源自引證詳實的生物仿制藥或自主研發的克隆產品。我們提供來源于人類或小鼠的細胞因子靶向和細胞因子受體靶向mAb。為保證最佳性能，每個批次均使用對應的報告細胞和重組細胞因子進行功能測試和驗證。
主要特點
• 重組單克隆抗體
• 源自引證詳實的生物仿制藥或自主研發的
• 產自CHO細胞
• 經過驗證的中和作用
• 驗證無內毒素
• 提供InvivoFitTM級別，可用于小鼠體內研究
應 用
• 中和試驗
• 檢測和生物活性試驗
• 篩選試驗
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InvivoGen中和抗體有哪些形式？ | |
| 生物仿制藥mAb 重組mAb，其特征是候選藥物或治療藥物的可變區和恒定區。 修飾同型的生物仿制藥mAb對原始同型進行了修飾的重組生物仿制藥mAb。 |
自主研發的mAb 產自InvivoGen特有的雜交瘤的重組mAb。在沒有可用的生物仿制藥的情況下開發。 InvivoFitTM mAbs具有鼠源可變區和恒定區的高質量重組mAb，專門針對小鼠體內研究。 |
|
  產品 |
靶點物種 | 克隆 | 同型 | 貨號 |
| 細胞因子抗體 | ||||
| Anti-hAPRIL-hIgG2 | Human | Sibeprenlimab biosimilar - CAS # 2382896-07-1 | Human IgG2 | hapril-mab2 |
| Anti-hBAFF-hIgG1 | Human | Belimumab biosimilar - CAS # 356547-88-1 | Human IgG1 | hbaff-mab1 |
| Anti-hCD40L-hIgG1 | Human | Frexalimab biosimilar - CAS #2515463-86-0 | Human IgG1 | h40l-mab1 |
| Anti-hIFN-α-hIgG1 | Human | Rontalizumab biosimilar - CAS #948570-30-7 | Human IgG1 | hifna-mab1 |
| Anti-hIFN-β-IgG | Human | Clone 10B10 | Mouse IgG2a | mabg2-hifnb-3 |
| Anti-hIFN-γ-hIgG1 | Human | Fontolizumab biosimilar - CAS #326859-36-3 | Human IgG1 | hifng-mab1 |
| Anti-hIL-1α-IgG1 | Human | Clone 7D4 | Human IgG1 | mabg-hil1a-3 |
| Anti-mIL-1α-mIgG1 | Mouse | Clone 6H7 | Mouse IgG1 | mil1a-mab9-02 |
| Anti-hIL-1β-IgG1 | Human | Clone 4H5 | Mouse IgG1 | mabg-hil1b-3 |
| Anti-mIL-1β-mIgG1 | Mouse | Clone 7E3 | Mouse IgG1 | mil1b-mab9-02 |
| Anti-mIL-2-mIgG1e3 | Mouse | Clone S4B6 | Mouse IgG1e3 (D265A) | mil2-mab15-02 |
| Anti-hIL-6-IgG | Human | Clone 3H3 | Mouse IgG1 | mabg-hil6-3 |
| Anti-mIL-6-mIgG1e3 | Mouse | Clone 10F9 | Mouse IgG1e3 (D265A) | mil6-mab15-02 |
| Anti-hIL-9-hIgG1 | Human | Enokizumab biosimilar - CAS #909875-08-7 | Human IgG1 | hil9-mab1 |
| Anti-hIL-10-hIgG1 | Human | Clone 20G2 | Human IgG1 | mab1-hil10 |
| Anti-hIL-12/IL-23-p40-hIgG1 |
Human | Ustekinumab biosimilar - CAS #815610-63-0 | Human IgG1 | hil12p40-mab1 |
| Anti-mIL-13-mIgG1 | Mouse | Clone 8H8 | Mouse IgG1 | mil13-mab9-02 |
| Anti-hIL-15-hIgG1 | Human | Ordesekimab biosimilar - CAS #879293-15-9 | Human IgG1 | hil15-mab1 |
| Anti-hIL-16-hIgG1 | Human | Clone 14.1 | Human IgG1 | hil16-mab1-02 |
| Anti-mIL-16-mIgG1e3 | Mouse | Clone 14.1 | Mouse IgG1e3 (D265A) | mil16-mab15-02 |
| Anti-hIL17A-hIgG1 | Human | Secukinumab biosimilar - CAS #1229022-83-6 | Human IgG1 | hil17a-mab1 |
| Anti-hIL-18-hIgG1-FES | Human | Camoteskimab biosimilar - CAS #2492472-82-7 | Human IgG1 (L242F/L243E/P339S) | hil18-mab16 |
| Anti-hIL-20-hIgG4 (S228P) | Human | Fletikumab biosimilar - CAS #1357158-22-5 | Human IgG4 (S228P) | hil20-mab14 |
| Anti-hIL-21-hIgG1 | Human | Avizakimab biosimilar - CAS #2229685-51-0 | Human IgG1 (M252Y/S254T/T256E) | hil21-mab1 |
| Anti-hIL-22-hIgG1 | Human | Fezakinumab biosimilar - CAS #1007106-86-6 | Human IgG1 | hil22-mab1 |
| Anti-hIL-25-hIgG1 | Human | Clone 15G10 | Human IgG1 | hil25-mab1 |
| Anti-hIL-28a-IgG | Human | Clone 21C3 | Mouse IgG1 | mabg-hil28a-3 |
| Anti-hIL-28b-IgG | Human | Clone 18F4 | Mouse IgG1 | mabg-hil28b-3 |
| Anti-mIL-28b-mIgG1 | Mouse | Clone 3C11 | Mouse IgG1 | mil28b-mab9-02 |
| Anti-hIL-29-mIgG1 | Human | Clone 6A11 | Mouse IgG1 | mab9-hil29 |
| Anti-hRANKL-hIgG2 | Human | Denosumab biosimilar - CAS #615258-40-7 | Human IgG2 (*) | hrankl-mab2 |
| Anti-hTGF-β-hIgG4 (S228P) | Human | Fresolimumab biosimilar - CAS #948564-73-6 | Human IgG4 (S228P) | htgfb-mab14 |
| Anti-hTL1A-hIgG1 | Human | Tulisokibart biosimilar - CAS #2648504-55-4 | Human IgG1 | htl1a-mab1 |
| Anti-hTNF-α-hIgG1 | Human | Adalimumab biosimilar - CAS #331731-18-1 | Human IgG1 (*) | htnfa-mab1 |
| Anti-hTSLP-hIgG2 | Human | Tezepelumab biosimilar - CAS #1572943-04-4 | Human IgG2 | htslp-mab2 |
| 細胞因子受體抗體 | ||||
| Anti-hEGFR-hIgG1 | Human | Cetuximab biosimilar - CAS #205923-56-4 | Human IgG1 | hegfr-mab1 |
| Anti-hGM-CSFR-hIgG4 (S228P) | Human | Mavrilimumab biosimilar - CAS #1085337-57-0 | Human IgG4 (S228P) | hgmcsfr-mab14 |
| Anti-hIFNAR-hIgG1-FES | Human | Anifrolumab biosimilar - CAS #1326232-46-5 | Human IgG1 (L242F/L243E/P339S) (*) | hifnar-mab16 |
| Anti-hIL1RAP-hIgG1 | Human | Nidanilimab biosimilar - CAS #2171061-85-9 | Human IgG1 | hil1rap-mab1 |
| Anti-hIL-3R-hIgG1-DE | Human | Talacotuzumab biosimilar - CAS #1826831-79-1 | Human IgG1 (S239D/I332E) | hil3r-mab18 |
| Anti-hIL-5R-hIgG1fut | Human | Benralizumab biosimilar - CAS #1044511-01-4 | Human IgG1 | hil5r-mab13 |
| Anti-hIL6R-To-hIgG1 | Human | Tocilizumab biosimilar - CAS #375823-41-9 | Human IgG1(*) | hil6rto-mab1 |
| Anti-hIL-31R-hIgG2 | Human | Nemolizumab biosimilar - CAS #1476039-58-3 | Human IgG2 | hil31r-mab2 |
| Anti-hIL-33R-hIgG2 | Human | Astegolimab biosimilar - CAS #2173054-79-8 | Human IgG2 | hil33r-mab2 |
| Anti-hIL-36R-hIgG4 (S228P) | Human | Imsidolimab biosimilar - CAS #2102543-86-0 | Human IgG4 (S228P) | hil36r-mab14 |
| 產品 | 克隆 | 同型 | 貨號 |
| INVIVOFITTM MOUSE CYTOKINE ANTIBODIES | |||
| Anti-mIL-1α-mIgG1 InvivoFit™ | Clone 6H7 | Mouse IgG1 | mil1a-mab9-1 |
| Anti-mIL-1β-mIgG1 InvivoFit™ | Clone 7E3 | Mouse IgG1 | mil1b-mab9-1 |
| Anti-mIL-2-mIgG1e3 InvivoFit™ | Clone S4B6 | Mouse IgG1e3 (D265A) | mil2-mab15-1 |
| Anti-mIL-6-mIgG1e3 InvivoFit™ | Clone 10F9 | Mouse IgG1e3 (D265A) | mil6-mab15-1 |
| Anti-mIL-13-mIgG1 InvivoFit™ | Clone 8H8 | Mouse IgG1 | mil13-mab9-1 |
| Anti-mIL-16-mIgG1e3 InvivoFit™ | Clone 14.1 | Mouse IgG1e3 (D265A) | mil16-mab15-1 |
| Anti-mIL-28b-mIgG1 InvivoFit™ | Clone 3C11 | Mouse IgG1 | mil28b-mab9-1 |
| 相關產品 | 貨號 |
| Cytokine Antagonist Screening Service | cytk-ant |
| Anti-β-Gal-hIgG1 (control*) | bgal-mab1 |
| Anti-β-Gal-mIgG1 InvivoFit™ (control*) | bgal-mab9-1 |
INVIVOFITTM GRADE
InvivoFit™是專為體內研究設計的高質量標準。InvivoFit™產品經0.2μm過濾除菌，并在嚴格的無菌條件下罐裝。各批次產品的細菌污染物(內毒素和脂蛋白)水平均通過瘊試劑盒(LAL)檢測以及TLR2和TLR4報告細胞檢測進行驗證。
(*) 多種同型可供選擇，詳情請聯系我們的代理商欣博盛生物，或訪問我們的網站。
更多詳情請聯系 InvivoGen 中國授權代理-欣博盛生物
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