血管緊張素是來源于血管緊張素原的小肽。幾種已知的血管緊張素是調節血壓的既定內分泌效應物，但它們也已知在一些器官和組織（旁分泌）和細胞水平（自分泌/內分泌）具有其他局部功能。血管緊張素I(DRVYIHPFHL)沒有已知的效應器功能，但它是血管緊張素II(DRVYIHPF)的直接前體。血管緊張素II與AT1受體結合，促進血管收縮、鈉潴留、醛固酮的釋放、氬加壓素的釋放、細胞增生、炎癥、纖維化、焦慮和心臟肥大。血管緊張素A(ARVYIHPF)，和血管緊張素III(RVYIHPF)，也與AT1受體結合。血管緊張素(1-7)(DRVYIHP)結合不同的受體，稱為MAS-1，具有相反的作用（血管擴張、利尿、抗擴散、NO釋放、PGE釋放和細胞凋亡）。血管緊張素IV(VYIHPF)與另一個稱為AT4(IRAP)的受體結合，促進血流增加、血管生成和利尿，它也與記憶的形成和阿爾茨海默病的發病機制有關。肽LVV-hemorphin-7（LVVYPWTQRF）不是血管緊張素，但也能與AT4受體結合。還有其他已經確定的血管緊張素肽，包括Ang(1-9)(DRVYIHPFH)、Ang(1-12)(DRVYIHPFHLVI)、Ang V(3-7)(VYIHP)，以及其他幾種功能未定的短肽。
ENZO Angiotensin II ELISA kit是一種比色競爭法免疫檢測試劑盒，3.5小時內即可得到結果。
● 高度特異性，與類似肽交叉反應性低
● 超越半定量Western blot分析的全定量檢測
● 易于使用的液體顏色編碼試劑，最大限度地減少錯誤
● 即用型試劑和預包被板可減少錯誤并節省您的時間
產品信息
|
產品貨號 |
ADI-900-204 |
|
產品名稱 |
Angiotensin II ELISA kit（血管緊張素ⅡELISA試劑盒） |
|
規格 |
96 wells |
|
靈敏度 |
4.6 pg/ml |
|
檢測范圍 |
3.9-10,000 pg/ml |
|
檢測時間 |
3.5 hours |
|
樣本種屬 |
Species independent |
|
樣本類型 |
plasma and serum |
|
保存溫度 |
Store all components at +4oC, except Standard at -20oC. |
|
試劑盒組分 |
Microtiter Plate, Conjugate, Antibody, Assay Buffer 16, Wash Buffer Concentrate, Standard, TMB Substrate, Stop Solution 2, Streptavidin-HRP |
部分產品引用文獻
1. ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury: T. Minato, et al.; PLoS One 17, e0270920 (2022)
2. Angiotensin II induces reactive oxygen species, DNA damage, and T-cell apoptosis in severe COVID-19: L. Kundra, et al.; J. Allergy Clin. Immunol. 150, 594 (2022)
3. Maternal perfluorooctane sulfonic acid exposure during rat pregnancy causes hypersensitivity to angiotensin II and attenuation of endothelium-dependent vasodilation in the uterine arteries: S.V. Dangudubiyyam, et al.; Biol. Reprod. 107, 1072 (2022)
4. Rapeseed (canola) oil aggravates metabolic syndrome-like conditions in male but not in female stroke-prone spontaneously hypertensive rats (SHRSP): M. Nishikawa, et al.; Toxicol. Rep. 9, 256 (2022)
5. Vasorin plays a critical role in vascular smooth muscle cells and arterial function: L. Louvet, et al.; J. Cell. Physiol. 237, 3845 (2022)
6. ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury: T. Yamaguchi, et al.; Nat. Commun. 12, 6791 (2021)
7. Advanced Oxidation Protein Product Promotes Oxidative Accentuation in Renal Epithelial Cells via the Soluble (Pro)renin Receptor-Mediated Intrarenal Renin-Angiotensin System and Nox4-H2O2 Signaling: K. Xue, et al.; Oxid. Med. Cell. Longev. 2021, 5710440 (2021)
8. Letter to the Editor - Circulating plasma levels of angiotensin II and aldosterone in patients with coronavirus disease 2019 (COVID-19): A preliminary report: B.M. Henry, et al.; Prog. Cardiovasc. Dis. 63, 702 (2021), Application(s): Human plasma
9. Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19: S. Espino-Y-Sosa, et al.; Viruses 13, 1906 (2021)
10. The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome: M. Punapart, et al.; Genes (Basel) 12, 1717 (2021)
11. B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction: T. Minato, et al.; Nat. Commun. 11, 1058 (2020)
12. Diabetes-induced Upregulation of Kallistatin Levels Exacerbates Diabetic Nephropathy via RAS Activation: Y. Yang, et al.; FASEB J. 34, 8428 (2020)
13. Serum ACE-2, angiotensin II, and aldosterone levels are unchanged in patients with COVID-19: M. Reider, et al.; Am. J. Hypertens. 2020, hpaa169 (2020)
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