Small GTPases of the Rab-family are crucial elements of the machinery that controls membrane traffic. Rab11 has been shown to control traffic through the recycling endosome.

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Rab12 protein is a member of the Rab subfamily of Ras-related small GTPases. Rab12 might regulate vesicular trafficking.

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he HER-2/neu oncogene, a member of the epidermal growth factor receptor or erb-B gene-like family

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B-Raf is a member of the Raf family of Ser/Thr protein kinases.

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Small GTPases are a super-family of cellular signaling regulators.

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EGFR is a receptor tyrosine kinase binding ligands of the EGF family

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The A146P mutation of KRas results in an amino acid substitution at position 146, from an alanine to a threonine. KRAS encodes a protein that is a member of the small GTPase

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Rab7A belongs to the Rab family of small GTPases. Rab7A is located in the late endosome, lysosome, cytoplasmic

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The protein FGFR1 is highly conserved between members and throughout evolution.

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Clusterin (apolipoprotein J) belongs to the clusterin family, is a 75 - 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apopto

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