女人与狗锁死了视频大全|霍金死亡过程恐怖视频|无节社团简谱季免费观看|六间房直播大厅|中文字幕欧美另类精品|久久人人玩人妻潮喷内射人人|亚洲国产一区二区三区在线观看

大量研究表明，癌癥是由基因突變引起，基因突變可以由致癌劑引起，也可由DNA代謝過程中產生的堿基錯配引起。為了確保遺傳物質的完整和穩定，細胞有許多防止基因突變的系統，其中包括切除修復、直接修復、重組修復和錯配修復。DNA損傷修復系統不僅通過矯正在DNA重組和復制過程中產生的堿基錯配而保持基因組的穩定性，而且通過誘導DNA損傷細胞的凋亡而消除由突變細胞生長形成的癌變。

Novus提供大量與DNA損傷和修復研究相關的產品，方便廣大科研用戶。

產品引用文獻：

1. [53BP1 Antibody NB100-904] Coleman KA, Greenberg RA. The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection. J Biol Chem. 2011 Feb 18. [PMID 21335604]
2. [53BP1 Antibody NB100-904] Zhang Y-W, Regairaz M, Seiler JA, et al. Poly(ADP-ribose) polymerase and XPF- ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. Nucleic Acids Res. 2011.[PMID 21227924]
3. [53BP1 Antibody NB100-304] Zhang M, Atkinson RL, Rosen JM. Selective targeting of radiation-resistanttumor-initiating cells. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3522-7. [PMID: 20133717]
4. [Blooms Syndrome Protein Blm Antibody (NBP1-46851] Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID, Pommier Y. Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Mol Cell Biol. 2005 Oct;25(20):8925-37.
5. [Blooms Syndrome Protein Blm Antibody NBP1-46851] Shimura T, Torres MJ, Martin MM, Rao VA, Pommier Y, Katsura M, Miyagawa K, Aladjem MI. Bloom’s syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. J Mol Biol. 2008 Jan 25;375(4):1152-64.
6. [FANCD2 Antibody NB100-182] Lyakhovich A, Surrallés J. Constitutive activation of caspase-3 and Poly ADP ribose polymerase cleavage in fanconi anemia cells. Mol Cancer Res. 2010 Jan;8(1):46-56. [PMID: 20068062]
7. [Ogg1 Antibody NB100-106] Karihtala P, Kauppila S, Puistola U, Jukkola-Vuorinen A. Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype. Br J Cancer. 2011 Nov 22. [PMID 22108520]

更多與癌癥相關的產品與文獻，請點擊如下鏈接：

http://www.novusbio.com/research-areas/cancer.html