趨化因子是一組具有趨化作用的細(xì)胞因子，能吸引免疫細(xì)胞到免疫應(yīng)答局部，參與免疫調(diào)節(jié)和免疫病理反應(yīng)。它們多為小于100個(gè)氨基酸的小分子多肽，根據(jù)結(jié)構(gòu)可主要分為4個(gè)趨化因子亞家族：Cys-X-Cys(CXC)、Cys-Cys(CC)、Cys(C)、Cys-X3-Cys(CX3C) 亞家族（如下圖）。
CXC家族成員多數(shù)基因定位于第4對(duì)染色體，包括IL-8、IP-10(IFN inducible protein-10)、MGSA等，CC家族成員多數(shù)基因定位于第17對(duì)染色體，包括MIP-1α, β(macrophage inflammatory protein)、 MCP-1(macrophage chemotactic protein)、RANTES (regulated upon activation normal T expressed and secreted)等。C家族只有一個(gè)成員Lymphotactin，基因定位于1號(hào)染色體。CX3C家族也只有一個(gè)成員Fractalkine (neurotactin)，基因定位于第16對(duì)染色體。
CXC家族成員多數(shù)基因定位于第4對(duì)染色體，包括IL-8、IP-10(IFN inducible protein-10)、MGSA等，CC家族成員多數(shù)基因定位于第17對(duì)染色體，包括MIP-1α, β(macrophage inflammatory protein)、 MCP-1(macrophage chemotactic protein)、RANTES (regulated upon activation normal T expressed and secreted)等。C家族只有一個(gè)成員Lymphotactin，基因定位于1號(hào)染色體。CX3C家族也只有一個(gè)成員Fractalkine (neurotactin)，基因定位于第16對(duì)染色體。
PeproTech Chemokine(趨化因子)產(chǎn)品一覽表
| 系統(tǒng)名稱(chēng) | 功能名稱(chēng)（小鼠蛋白） | 應(yīng)答細(xì)胞（小鼠蛋白） | 已知受體 | 產(chǎn)品貨號(hào) |
| CXC Chemokines | ||||
| CXCL1 | GRO1, GRO-α, MGSA, NAP-3 (KC) |
PMN | CXCR1, CXCR2 |
300-11/400- 10/250-11 |
| CXCL2 | GRO2, GRO-β, MIP2-α (MIP-2) |
PMN | CXCR1, CXCR2 |
300-39/400- 11/250-15 |
| CXCL3 | GRO3, GRO-γ, MIP2-β (DCIP-1) |
PMN | CXCR2 | 300-40 |
| CXCL4 | PF-4, Oncostatin-A | PMN, Mo | CXCR3B | 300-16/250-39 |
| CXCL5 | ENA-78 | PMN | CXCR2 | 300-22/300-22B |
| CXCL6 | GCP-2, CKA-3 (LIX) | PMN | CXCR1, CXCR2 |
300-41/250- 36/250-17 |
| CXCL7 | NAP-2, PBP, LDGF, MDGF | PMN | CXCR1, CXCR2 |
300-14 |
| CXCL8 | IL-8, GCP-1, NAP-1 | PMN, Bs | CXCR1, CXCR2 |
200-08/200-08M |
| CXCL9 | MIG | actT [Th1], NK | CXCR3 | 300-26/250-18 |
| CXCL10 | IP-10 (CRG-2) | Mo, actT [Th1], NK | CXCR3 | 300-12/250- 16/400-33 |
| CXCL11 | I-TAC, IP-9 | actT [Th1], NK | CXCR3, CXCR7 |
300-46/250-29 |
| CXCL12 | SDF-1, SDF-1α/β, PBSF | All cell types | CXCR4, CXCR7 |
300-28A/250- 20A/400-32A/ 300-28B/250- 20B/400-32B |
| CXCL13 | BCA-1, BLC | B, (Mo) | CXCR5 | 300-47/250-24 |
| CXCL14 | BRAK, MIP-2G | PMN, mDC (B, Mo) | unknown | 300-50 |
| CXCL15 | (Lungkine) | PMN | unknown | 250-37 |
| CXCL16 | SR-PSOX | actT | CXCR6 | 300-55/250-28 |
| CXCL17 | VEGF co-regulated chemokine 1, DMC |
Mo, iDC | unknown | |
| C Chemokines | ||||
| XCL1 | Lymphotactin, ATAC, SCM-1 | Tr | XCR1 | 300-20 |
| XCL2 | SCM-1β | Tr | XCR1 | |
| CX3C Chemokine | ||||
| CX3CL1 | Fractalkine, Neurotactin, CX3C |
Mo, actT, NK | CX3CR1 | 300-31/400-26 |
| CC Chemokines | ||||
| CCL1 | I-309 (TCA-3) | iDC, actT [Th2], Mo (PMN) |
CCR8 | 300-37 |
| CCL2 | MCP-1, MCAF, JE | Bs, Mo, actT, NK, iDC |
CCR2, CCR4 | 300-04/250-10/ 400-12 |
| CCL3 | MIP-1α, LD78α | Eo, Mo, actT, NK, iDC(PMN) |
CCR1,CCR4, CCR5 |
300-08/250-09/ 400-15 |
| CCL3L1 | LD78β | Mo, actT, B | CCR1,CCR3, CCR5 |
300-56 |
| CCL4 | MIP-1β , LAG-1 | Mo, actT [Th1], NK, iDC |
CCR5 | 300-09/250-32/ 400-09 |
| CCL4L1 | LAG-1 gene duplication | Mo | CCR1, CCR5 | 300-58 |
| CCL5 | RANTES | Eo, Bs, Mo, actT, NK, iDC, Tm |
CCR1, CCR3, CCR4,CCR5 |
300-06/250-07/ 400-13 |
| CCL6 | (C-10) | Mo | CCR1 | 250-06 |
| CCL7 | MCP-3 (FIC) | Eo, Bs, Mo, actT, NK, iDC |
CCR1,CCR2, CCR3 |
300-17/250-08 |
| CCL8 | MCP-2 | Eo, Bs, Mo, actT, NK, iDC |
CCR1, CCR2B, CCR3, CCR5 |
300-15/250-14 |
| CCL9/CCL10 | (MIP-1γ, MRP-2) | PMN, actT | CCR1 | 250-12 |
| CCL11 | Eotaxin | Eo, Bs, actT [Th2], iDC | CCR3 | 300-21/250-01 |
| CCL12 | (MCP-5) | Eo, Bs, Mo, actT, NK, iDC |
CCR2 | 250-04 |
| CCL13 | MCP-4, CKβ-10 | Eo, Bs, Mo, actT, NK, iDC |
CCR1,CCR2, CCR3 |
300-24 |
| CCL14 | HCC-1 | Eo, Mo, T | CCR1,CCR3, CCR5 |
300-38B/300-38 |
| CCL15 | MIP-5, MIP-1d, HCC-2, LKN-1 |
Mo, T | CCR1, CCR3 | 300-43 |
| CCL16 | LEC, HCC-4 | Mo, actT [Th1] | CCR1 | 300-44 |
| CCL17 | TARC (ABCD-2) | actT [Th2] | CCR4 | 300-30 |
| CCL18 | MIP-4, DC-CK1, PARC, AMAC-1 |
Tr, iDC | unknown | 300-34 |
| CCL19 | MIP-3β, ELC, Exodus-3, CKβ-11 |
Tr, actT, mDC | CCR7 | 300-29B/250-27B |
| CCL20 | MIP-3α, LARC, Exodus-1 | Tm, B, iDC, PMN | CCR6 | 300-29A/250-27 |
| CCL21 | Exodus-2, 6Ckine, SLC | Tr, actT, mDC | CCR7 | 300-35/250-13 |
| CCL22 | MDC, STCP-1 (ABCD-1) | Mo, actT [Th2], NK, iDC |
CCR4 | 300-36/300- 36A/250-23 |
| CCL23 | MIP-3, MPIF-1, CKβ-8 | PMN, Mo, Tr | CCR1 | 300-29 |
| CCL24 | Eotaxin-2, MPIF-2, CKβ-6 | Eo, Bs, actT [Th2], iDc,PMN, Tr |
CCR3 | 300-33/250-22 |
| CCL25 | TECK | Thymocytes, Tr, iDC | CCR9 | 300-45 |
| CCL26 | MIP-4α, Eotaxin-3 | Eo, Bs, actT [Th2], iDC | CCR3 | 300-48 |
| CCL27 | CTACK, ILC, Eskine | actT | CCR10 | 300-54/250-26 |
| CCL28 | MEC | actT, Tr, Eo | CCR3, CCR10 | 300-57/250-30 |
Tips：
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Tm = memory T cells
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B = B-cells
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actT = activated T cell
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Bs = Basophil
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Tr = resting T cell
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T = T cells
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Eo = Eosinophil
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NK = Natural Killer cells
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Mo = monocyte
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PMN = neutrophils
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mDC = mature dendritic cells
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iDC = immature dendritic cells
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