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腫瘤細(xì)胞最重要的生物學(xué)特征是無限制的快速增殖，為了滿足其快速增殖的需要，腫瘤細(xì)胞表現(xiàn)出與正常細(xì)胞不同的代謝特征。早在1924年Otto Warhurg就發(fā)現(xiàn)腫瘤細(xì)胞在葡萄糖的利用上與正常細(xì)胞不同，即腫瘤細(xì)胞更喜歡將葡萄糖進(jìn)行糖酵解轉(zhuǎn)變?yōu)槿樗幔皇窍裾＜?xì)胞那樣經(jīng)三羧酸循環(huán)（TCA cycle）由線粒體氧化磷酸化產(chǎn)生三磷酸腺苷（ATP），即使在氧氣充足的情況下也是如此。最早對此現(xiàn)象的解釋是Warburg本人于1956年提出，而后來研究者發(fā)現(xiàn)在大多數(shù)腫瘤細(xì)胞中線粒體的功能并未受損，說明Warburg現(xiàn)象是由其他原因造成的。隨著人們對腫瘤研究的逐步深入，腫瘤細(xì)胞的代謝途徑以及調(diào)控已經(jīng)得到初步闡明。

Novus提供大量與腫瘤代謝相關(guān)的產(chǎn)品，方便廣大科研用戶。

產(chǎn)品引用文獻(xiàn)：

1. [ADFP Antibody NB110-40877] Wohlers LM, Jackson KC, Spangenburg EE. Lipolytic signaling in response to acute exercise is
   altered in female mice following ovariectomy. J Cell Biochem. 2011 Aug 3. [PMID: 21815195]
2. [ARH Antibody NB100-1276] Ye Z-J, Go G-W, Singh R, et al. LRP6 regulates LDLR-mediated
   LDL uptake. The Journal of Biological Chemistry. 2011 Nov 28. [PMID: 22128165]
3. [Cytochrome P450 17A1 Antibody NB100-2842] Efstathiou E, Titus M, Tsavachidou D, Tzelepi V,
   Wen S, Hoang A, Molina A, Chieffo N, Smith LA, Karlou M, Troncoso P, Logothetis CJ. Effects of abiraterone acetate
   on androgen signaling in castrate-resistant prostate cancer in bone. J Clin Oncol. 2012 Feb 20;30(6):637-43. [PMID: 22184395]
4. [Cytochrome P450 17A1 Antibody NB100-92420] Jeong CW, Yoon CY, Jeong SJ, et al.
   Limited expression of cytochrome p450 17[alpha]-hydroxylase/17,20-lyase in prostate cancer cell lines.
   Korean J Urol. 2011 Jul;52(7):494-497. [PMID: 21860772]
5. [MRP4 Antibody NB100-1471] Naud J, Michaud J, Beauchemin S, et al. Effects of chronic renal failure
   on kidney drug transporters and cytochrome P450 in rats.Drug Metab Dispos. 2011 Aug;39(8):1363-9. [PMID 21525170]
6. [OSBP1 Antibody NB100-1500, OSBPL10 Antibody NB100-2448, OSBPL11 Antibody NB100-1337,
   OSBPL2 Antibody NB100-1332 and OSBPL9 Antibody NB100-1336] Storey SM, McIntosh AL, Huang H, et al.
7. Intracellular Cholesterol Binding Proteins Enhance HDL-mediated Cholesterol Uptake in Cultured
   Primary Mouse Hepatocytes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2012 Jan 12.
8. [PMID: 22241858]
9. [PDK1 Antibody NB100-2383] Luo W, Hu H, Chang R, et al. Pyruvate Kinase M2 is
   a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1.Cell. 2011 May 27;145(5):732-44. [PMID: 21620138]
10. [PDK1 Antibody NB100-2384] Lin HP, Jiang SS, Chuu CP. Caffeic Acid Phenethyl Ester
    Causes p21 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate
    Cancer Cells. PLoS One. 2012;7(2):e31286. [PMID: 22347457]

歡迎使用Novus Explorer搜索與脂類代謝研究相關(guān)的產(chǎn)品與文獻(xiàn)，鏈接為：http://www.novusbio.com/explorer。