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腫瘤干細胞（Cancer stem cell, CSC）假說是近年來提出的關于腫瘤發生的新概念，在所有的腫瘤細胞中，可能只有小部分細胞具有產生腫瘤并維持腫瘤生長和異質性的能力，這一小部分細胞被稱作腫瘤干細胞。目前已經在白血病、乳腺癌、腦癌等腫瘤組織中成功分離出了腫瘤干細胞，深入了解腫瘤干細胞的生物學特性、發展相應的鑒別方法以及特殊的治療手段對癌癥的臨床治療有著重要的意義。 腫瘤干細胞與正常干細胞有很多相似的特點，如二者都具有自我更新、可以產生大量分化細胞及擁有一些共同的表面標記。所不同的是正常干細胞在有序的調控下發揮自己的功能，如在正常的生理條件下，造血干細胞受到細胞周期調控因子p21與p18的調節，大部分時間都處于靜止狀態，當造血干細胞收到外界信號刺激后，才會進入自我更新或分化進程，維持組織的更新與修復，整個過程處于平衡狀態。而腫瘤干細胞分裂與分化是失控的，通過不斷自我更新與分化，最終產生大量的腫瘤細胞，維持著腫瘤的生長與異質性。 |
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Novus提供大量與腫瘤干細胞研究相關的產品，方便廣大科研用戶。 |  | |||||
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Catalog：NBP1-77687 Product: ABCB5 Antibody Species: Hu, Mu Applications: IF, ICC, IHC-P |
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Catalog：NB600-1071 Product: CD34 (MEC 14.7) Antibody Species: Mu Applications: ELISA, FACS, ICC, IF,IHC-Fr, IHC-P, IP, WB |
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Catalog：NBP1-44703 Product: CD34 (QBEnd-10) Antibody Species: Hu, Mk Applications: Func, FACS, IHC-Fr, IHC-P, IP, WB |
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Catalog：NBP1-86010 Product: CD38 Antibody Species: Hu Applications: IHC-P, WB |
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Catalog：NBP1-31488 Product: CD44 Antibody Species: Hu Applications: : ICC, IF, IHC-P, WB |
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Catalog：NBP1-42067 Product: CD90/Thy1 (EPR3132) Antibody Species: Hu, Rt Applications: ICC, IHC-P, WB |
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Catalog：NBP1-47729 Product: EpCAM (4G10) Antibody Species: Hu Applications: : IF, IHC-P, WB |
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Catalog：NBP1-95700 Product: EpCAM Antibody (EPR677(2)) Species: Hu Applications: ICC, IHC-P, WB |
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Catalog：M-009-100 Product: p75 NGF Receptor (MLR2) Antibody Species: GP, Hu, Mu, Rt Applications: FACS, IF, IHC-Fr, WB |
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相關指標 ABCB5 CD44 CD24 CD90 CD34 EpCAM CD38 p75 NGF Receptor |
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產品引用文獻： 1.[CD34 Antibody NB600-1071) Fiorina P, Pietramaggiori G, Scherer SS, et al. The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing. Cell Transplant. 2010;19(11):1369- 81. [PMID: 20977829] 2.[CD34 Antibody NB600-1071] Kalabis J, Oyama K, Okawa T, Nakagawa H, Michaylira CZ, Stairs DB, Figueiredo JL, Mahmood U, Diehl JA, Herlyn M, Rustgi AK. A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. J Clin Invest. 2008 Dec;118(12):3860-9. 3.[CD44 Antibody AP00142PU-N] Walker F, Zhang H-H, Odorizzi A, Burgess AW. LGR5 Is a Negative Regulator of Tumorigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell Lines. PLoSONE. 201. [PMID 21829496] 4.[EpCAM Antibody NB110-56958] Kalabis J, Oyama K, Okawa T, Nakagawa H, Michaylira CZ, Stairs DB, Figueiredo JL, Mahmood U, Diehl JA, Herlyn M, Rustgi AK. A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. J Clin Invest. 2008 Dec;118(12):3860-9. 5.[EpCAM Antibody NB110-56958] Ralhan R, Cao J, Lim T, et al, EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis ,BMC Cancer 10 (2010) 331 6.[EpCAM Antibody NB110-56958] Maetzel D, Denzel S, Mack B, et al, Nuclear signalling by tumor-associated antigen EpCAM ,Nature Cell Biology11 (2009) 162-171. (IP) 7.[p75 NGF Receptor Antibody M-009-100] Wiese S, Herrmann T, Drepper C, Jablonka S, Funk N, Klausmeyer A, Rogers ML, Rush RA & Sendtner M (2009) Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos. Nat Protoc. 2010;5(1):31-8 8.[p75 NGF Receptor Antibody M-006-100 and NGF Receptor Antibody NB100-1539] Davies A. et al (2010) The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a post translational modification essential for function Proc Natl Acad Sci U S A. Jan 26;107(4):1654-9 更多與癌癥相關的產品與文獻，請點擊如下鏈接： http://www.novusbio.com/research-areas/cancer.html |
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