凋亡細胞的清除對組織穩態和炎癥的修復很關鍵。MerTK是巨噬細胞表面的一類蛋白質，它能夠調節炎癥修復，效應細胞增生。通過與凋亡細胞表面翻轉的磷酯酰絲氨酸結合，能夠發生吞噬作用。此外，巨噬細胞還能夠抑制NF-KB信號通路。有研究表明，MerTK信號能夠促進SPM(炎癥損傷修復過程依賴于特定的調節因子)的合成。MerTK 在靜息巨噬細胞中及免疫抑制期間是作為一種耐受性受體。它屬于酪氨酸激酶受體中的TAM家族，在組織巨噬細胞中表達。因此，MerTK和CD64的雙重表達正成為巨噬細胞的界定標準，并幫助將組織巨噬細胞從樹突狀細胞中區分出來。
MerTK能調節巨噬細胞活化，促進凋亡細胞的吞噬，幫助血小板聚集，并維持體內血塊的穩定。MerTK在多種類型的癌癥中會發生過表達或異位表達，如白血病、非小細胞肺癌、黑色素瘤和前列腺癌等，這可能會導致若干典型的致癌信號傳導途徑的活化。
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Human monocyte-derived macrophages cultured in the presence of Human M-CSF Recombinant Protein (cat. 14-8789) and dexamethazone were stained with Anti-Human CD11b APC (cat. 17-0118) and Mouse IgG1 K Isotype Control PE (cat. 12-4714) (left) or Anti-Human MerTK PE (right). Total viable cells, as determined by Fixable Viability Dye eFluor? 450 (cat. 65-0863), were used for analysis. |
相關產品：
| 品牌 | 產品貨號 | 產品名稱 | 規格 | 目錄價 |
| eBioscience | 85-12-9043-41 | Anti-Human Mer PE 25 tests | 25 tests | 1287 |
| eBioscience | 85-12-9043-42 | Anti-Human Mer PE 100 tests | 100 tests | 3627 |
| eBioscience | 85-12-5751-80 | Anti-Mouse MerTK PE | 25 ug | 1157 |
| eBioscience | 85-12-5751-82 | Anti-Mouse MerTK PE | 100 ug | 3237 |
| eBioscience | 85-14-5751-80 | Anti-Mouse MerTK Purified | 25 ug | 1287 |
| eBioscience | 85-14-5751-82 | Anti-Mouse MerTK Purified | 100 ug | 3627 |
| eBioscience | 85-25-5751-80 | Anti-Mouse MerTK PE-Cyanine7 | 25 ug | 1807 |
| eBioscience | 85-25-5751-82 | Anti-Mouse MerTK PE-Cyanine7 | 100 ug | 4407 |