圖一. TJ-004309藥品研發進展（數據來源：藥渡）
免疫逃逸的幫兇
圖二. CD39-CD73作用機制（來源：Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies）
巨頭青睞，多款藥物邁入臨床
數據來源：藥渡
ACRO自主研發高酶活CD39/CD73系列
為加速CD39/CD73藥物研發，ACROBiosystems提供CD39和CD73高酶活系列產品，純度和活性經過驗證并且可以免費提供活性驗證Protocol，以供客戶進行抗體藥物免疫與篩選。
| 貨號 | 商品名稱 | 種屬 |
| CD9-H52H4 | Human CD39 / ENTPD1 Protein, His Tag (active enzyme) | Human |
| CD9-H82E5 | Biotinylated Human CD39 / ENTPD1 Protein, His,Avitag? (MALS verified) (active enzyme) | Human |
| CD9-H5253 | Human CD39 Protein, Mouse IgG2a Fc Tag | Human |
| CD3-H52H7 | Human CD73 / NT5E Protein, His Tag (HPLC-verified) (active enzyme) | Human |
| CD3-M52H9 | Mouse CD73 / NT5E Protein, His Tag (active enzyme) | Mouse |
| CD3-H82E3 | Biotinylated Human CD73 / NT5E Protein, His,Avitag? | Human |
| CD3-H5252 | Human CD73 Protein, Mouse IgG2a Fc Tag (active enzyme) | Human |
| CD3-C52H9 | Cynomolgus CD73 Protein, His Tag (active enzyme) | Cynomolgus |
| CD3-H525x | Human CD73 / NT5E Protein, Fc Tag | Human |
此外，基于我司豐富的蛋白產品資源和活性分析經驗，您只需提供樣品，即可為您提供高質量SPR/BLI親和力檢測服務。
>測定產品Human CD39 / ENTPD1 Protein, His Tag水解底物腺苷-5 ' -三磷酸(ATP)中的5 ' -磷酸基團的活性，結果顯示在相同測定條件下，ACRO產品（Cat. No.CD9-H52H4）酶活> 6,000 pmol/min/μg，競品酶活> 5,000 pmol/min/μg。
>測定產品Human CD73 / NT5E Protein, His Tag (HPLC-verified)水解底物腺苷-5 ' -單磷酸(AMP)中的5 ' -磷酸基團的活性, 結果顯示在相同測定條件下，ACRO產品（Cat. No.CD3-H52H7）酶活> 37,000 pmol/min/μg，競品酶活>15,000 pmol/min/μg。
>>>> 高生物活性
ELISA
Immobilized Human CD39, His Tag (Cat. No. CD9-H52H4) at 1 μg/mL (100 μL/well) can bind Anti-CD39 Antibody, Human IgG1 with a linear range of 0.1-0.8 ng/mL (QC tested).
SPR
Anti-CD73 antibody (Human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human CD73, His Tag (HPLC-verified) (Cat. No. CD3-H52H7) with an affinity constant of 0.164 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
您可通過以下方式聯系到ACROBiosystems：
郵件：inquiry@acrobiosystems.com
電話：18811625790
（備注：姓名+公司）